I know some people who have shifted from being addicts to being permanently psychologically challenged. Most of them have already stopped their addiction but they have developed psychotic symptoms which would suddenly be triggered from time to time. The toxic substances in the drugs and substances might have been the root cause of their psychological problems because those symptoms only came out when they became addicted. I guess this just goes to show that addiction can lead to different things such as permanent illness and even death. Lucky are those who recognized their problems early and were able to change before it's too late.