I have just made a post in the 'other substances' forum about Ibuprofen, after taking it to eliminate a headache and ending up getting a buzz from taking it. I looked up online to find out if you could 'high' from it and the general consensus was no, you can't. I also saw a lot of information which suggests that Ibuprofen counteracts the effects of marijuana, therefore you cannot get 'high' on marijuana if you are taking Ibuprofen. I can't imagine that this is true, but if it is, then it's something that people who use marijuana to eliminate pain may want to consider. Obviously, it's no good becoming dependent on a different drug instead but the main difference here is that marijuana is smoked whereas Ibuprofen isn't.