I had a friend who played guitar really well. He kept trying to quit smoking for various reasons, not the least of which was it can cost quite a bit. Anyway, he would just find himself getting frustrated because when he wasn't smoking he couldn't play his guitar. He said he was always high from the first time he tried to play and that when he wasn't he just couldn't seem to connect with it. Couldn't feel the music, I suppose, if he wasn't high. I'm of the opinion that if he'd just held out for awhile he'd have found his connection again, but I'll never know. He has since died in a motorcycle accident.