This problem is very serious and it has been here fore some time now. Popping pills in the club is dangerous in many levels and one of those is the fact that sometimes you don't know what you get. Still, kids do it and do some stupid stuff afterwards. I believe that not one smart thing was ever done after taking pills in the club.
Seemingly innocent looking people can hide a lot secrets Looks can be deceiving. As for the estrangement... are they sure it wasn't one of those incident in which they use this as some sort of erotic practice? Maybe they were trying to do that, and something went horribly wrong.