I'm sure your friend already knows it, she's probably just in denial of what's going on. If you are really friends, it would be alright to have a calm and concerned talk with her and tell her what you really think. Also, offer some solutions or how you may be able to help. Sometimes, people are in denial because they are afraid that they will go through the problem all by themselves and that there is a stigma attached to the situation. Assure your friend you will be there and also assure her that she will be able to move past this situation.