Nearly half of the nations over 41,340 overdose deaths in 2011 involved prescription painkillers like oxycodone and hydrocodone. These drugs now kill more adults than cocaine and heroin combined. An even more powerful pain killer was recently approved by FDA despite the disapproval of its own expert advisory committee. This drug is Zohydro which is being used by people suffering from chronic pain. Now my concern is: Which is the best and safest prescription painkiller available for chronic pain? A friend of mine with pain problems is really concerned about the use of these drugs.